With the accelerating process of transformation and upgrading of China’s manufacturing industry, employers’ requirements for the professional qualities and skills of technical workers are increasing day by day. As the core value to promote high-quality development, the craftsman spirit has become an important part of vocational education. Taking the Mechanical Foundation course of the mechanical major in a technician college as an example, this study tracked and analyzed the teaching effect of integrating the craftsman spirit into the course for one academic year. By comparing the performance of students before and after integrating the craftsman spirit into daily teaching, it explored its influence on students’ professional skills, innovation ability, and professional qualities. The study collected data through questionnaires, classroom observations, etc., providing a practical basis for the promotion of the craftsman spirit in vocational education and curriculum reform in the future.