Under the background of the era of rapid development of the meta-universe, the fusion of virtual and reality in new media art creation has become a key trend. Starting from the concept of meta-universe and new media art, this paper analyzes the connection between the two in depth, elaborates on the manifestation of the fusion of virtual and reality in new media art creation, explores the challenges and problems it faces, and puts forward coping strategies with the aim of providing theoretical support for the development of the creation of new media art under the context of the meta-universe, and promoting the innovation and progress of art creation.