Against the backdrop of the advancement of the “Double High Plan” and the deepening of the strategy for building a cultural powerhouse, aesthetic education in architectural interior design in higher vocational colleges faces dual demands for “cultural empowerment” and “skill enhancement.” Currently, prominent issues exist in this field, such as superficial integration of regional culture, disconnection between aesthetic education and professional skill training, and a lack of systematic infiltration paths. This study primarily takes regional culture in Sichuan and Chongqing as research samples, employing literature research, mixed research methods, case analysis, and action research. By analyzing the current status and dilemmas of aesthetic education practices, it constructs a four-dimensional integrated infiltration path for aesthetic education encompassing “resources-implementation-guarantee-evaluation.” This research not only provides an operable practical paradigm for aesthetic education reform in design-related majors in higher vocational colleges but also supports the living transmission of regional culture in Sichuan and Chongqing.