Against the backdrop of the accelerated application of artificial intelligence, courses integrating specialty education and innovation-entrepreneurship education still face challenges such as the disconnection between learning and application, imbalance in collaboration, and insufficient educational effectiveness. Taking the course E-commerce Innovation and Entrepreneurship as an example, this study introduces the perspective of scenario innovation and constructs a teaching mechanism centered on real value-creation scenarios and supported by “teacher-student-machine” collaboration. The paper elaborates on its operational mechanism from three dimensions: content reconstruction, collaborative operation, and immersive education. A closed-loop educational model characterized by “structural optimization, process collaboration, and value accumulation” is thus formed. This study expands the explanatory framework of scenario innovation and human-machine collaboration in innovation and entrepreneurship education, and provides references for the integration of specialty and innovation education and AI-empowered teaching reform in the New Liberal Arts context.