Against the backdrop of continuous advancement of the “Dual Carbon” strategy, hydrogen energy has become an important direction for China’s energy structure transformation. The rapid development of the hydrogen energy and fuel cell industry has raised higher requirements for compound talents with theoretical foundation, engineering practical ability and interdisciplinary literacy. At present, the course Hydrogen Energy and Fuel Cell still has contradictions between limited class hours and complicated knowledge systems, outdated textbook contents lagging behind industrial technology iteration, insufficient practical teaching resources and uneven regional distribution of industrial chains. Traditional cramming teaching can hardly meet the demands of cultivating application-oriented talents. Based on the concept of industry-education integration, this paper reconstructs three types of engineering project modules including low-carbon hydrogen production process design, fuel cell stack performance optimization and deduction of cutting-edge hydrogen energy technologies, and constructs a dual-line integrated teaching path of “online autonomous learning — offline collaborative discussion — project achievement presentation”. Meanwhile, an outcome-oriented assessment system consisting of self-evaluation, team mutual evaluation as well as evaluation by teachers and enterprise experts is established. The reform aims to connect basic theories with industrial practice, and improve students’ capabilities in engineering design, techno-economic analysis, teamwork and high-order critical thinking, so as to provide references for cultivating application-oriented talents in the hydrogen energy field.