With the wave of knowledge economy sweeping, knowledge-based employees play an important role in achieving sustainable development of enterprises. Therefore, how to formulate scientific and effective incentive measures to retain them has become an important topic to be overcome in modern enterprise human resource management. According to the problems of enterprises such as monotonous incentive methods, lack of objective performance evaluation systems, single incentive objects and lack of fairness and justice in measures. We will respond by shaping an excellent corporate culture, building a scientific salary system, paying attention to the growth of knowledge-based employees, and adopting diversified incentive methods.