With the constant changes of the times, China’s science and technology have entered a period of rapid development. At the same time, the economic structure is also changing with the changes of the times, and the original Haikou logistics industry in the process is also facing new impacts and challenges. And related enterprises want to stand out in the fierce market competition, we must optimize and upgrade the current industry development situation, promote the integrated development of Haikou logistics and manufacturing industry, to constantly promote the innovative application of digital technology in the logistics industry and manufacturing industry, the formation of a multi-force economic development model. This paper mainly starts with the development status of Haikou logistics, analyzes the importance of the integration of Haikou logistics and manufacturing industry under the background of big data drive, and makes an in-depth discussion on the path of the integration of Haikou logistics and manufacturing industry under the drive of big data, hoping to contribute new strength to the development of social economy.