With the deepening of education digitization and the construction of new medical disciplines, the limitations of traditional medical education models in resource integration, teaching collaboration, and cross-regional development have become increasingly prominent. This article focuses on the innovation of the medical education system in the information age, taking the construction of a clinical virtual teaching and research office in pediatrics as a practical sample, systematically exploring the construction logic and implementation path of a new type of grass-roots teaching organization. The study points out that the virtual teaching and research office forms a “four-in-one” logical framework by reconstructing its target positioning, organizational structure, and operational guarantee mechanism: taking medical-educational collaboration as the core goal, following the principles of cross-domain linkage and resource sharing, establishing a multi-level collaboration network, and achieving sustainable operation through institutional innovation and technological empowerment.