With the full implementation and explosion of artificial intelligence big models such as DeepSeek, Doubao and Dream, the business of many traditional industries has been more or less affected. However, with its super data processing ability and intelligent analysis ability, it has been warmly welcomed and widely used in the industry, and has also given rise to some innovative changes in the development of various industries. In this wave of artificial intelligence, AI technology is also constantly infiltrating into the field of education and mental health work, and the mental health work of college students is also ushering in new development and opportunities. This study investigates the application of AI technology in college students' psychological work, and analyzes that the application of AI technology can promote the breadth coverage and accuracy of college students' psychological work, and effectively improve the quality and efficiency of college students' mental health work. However, due to the limitations of AI technology's own data calculation and objective existing data security problems, the application of AI technology can effectively improve the quality and efficiency of college students' mental health work. There may be certain deviations in the actual work process. Based on the above analysis, this paper can be used as a discussion on the application of AI technology in college students' mental health work.