In response to the problems existing in the teaching of unmanned systems courses, such as being confined to traditional teaching models and insufficient focus on practical application, this paper proposes to guide the teaching with the OBE concept, carry out the teaching goal planning of unmanned systems application based on the OBE concept, innovate teaching methods, reconstruct course content, revitalize the teaching process, improve the evaluation model, and stimulate learning motivation to enhance the quality of course teaching and achieve the teaching goal of “knowledge + ability.” This has a certain reference value for the reform practice of unmanned systems courses.