College students’ safety education is an important part of the fundamental task of fostering virtue through education in colleges and universities. A questionnaire survey at J University shows that the popularization degree and teaching satisfaction of college students’ safety education are relatively high, but the teaching content and teaching forms still need improvement. With the rapid development of artificial intelligence technology and considering the characteristics of college students’ online learning in the new era, carrying out the SPOC + PBL blended teaching reform not only helps to enhance the effectiveness of theoretical and practical teaching but also contributes to optimizing the teaching evaluation and feedback mechanism and strengthening students’ problem-solving abilities. Therefore, we should adhere to the goal orientation, meticulously design the teaching plan, highlight the student-centered approach, focus on integrating teaching resources, strengthen process management, promptly provide feedback and guidance, empower with data, and continuously improve teaching evaluation. Thus, a student-centered SPOC + PBL blended teaching system can be constructed to empower the transformation and innovation of talent cultivation in higher education.