Teenagers are in the special stage of physical and mental development, and their psychological problems show complex and diverse characteristics. Depression is the most common mental disorder among teenagers. Literary reading has a certain intervention effect on depression and can be used as an important strategy for psychological intervention. Reading literature works can help teenagers understand and discover themselves from different angles, and then realize the self-recognition and intervention of depression. This paper mainly discusses the causes of depression in teenagers and the intervention principles and strategies of literary reading on depression, aiming to alleviate and eliminate the depressive symptoms of teenagers through literary reading and promote their physical and mental health development.