As there are numerous physics formulas in addition to them being theoretical, college students generally consider the concepts of physics as abstract, in which they are not able to apply what they have learned. For 3D dynamic animation and visualization in the teaching of college physics, VPyton has many advantages, and it provides useful exploration for students to overcome obstacles in college physics learning. Taking the teaching of simple harmonic vibration, optics, molecular thermal motion, and electric field as examples, this article discusses the application of VPython in the human-computer interactive teaching mode of college physics, which provides a beneficial exploration and new way to improve students’ engineering skills and numeracy, as well as to respond to the national “new engineering education” reform in China.