Driven by the technological revolution and industrial transformation, the digital and intelligent transformation of education is accelerating. Big data and artificial intelligence (AI) technologies have been widely applied in the cross-border e-commerce industry, raising higher requirements for professional knowledge, comprehensive qualities, and practical capabilities of cross-border e-commerce talents. Combining the typical application scenarios of AI in cross-border e-commerce, this paper analyzes the existing problems in the teaching of cross-border e-commerce majors in higher vocational colleges and constructs the core framework of AI-enabled professional teaching. Focusing on curriculum development, practical training scenarios, faculty building, and evaluation mechanisms, this paper explores targeted countermeasures for AI-driven teaching reform, so as to provide references for cultivating application-oriented talents who can adapt to the intelligent transformation of the cross-border e-commerce industry.