Against the backdrop of the integrated development of the digital economy and the digital transformation of education, artificial intelligence has become a core engine for the reform of innovation and entrepreneurship education in universities, offering a new approach to addressing problems such as homogeneity and insufficient practice in traditional education. Based on the demand for high-quality development of innovation and entrepreneurship education in universities and combined with the application practice of artificial intelligence, this paper explores the specific implementation paths enabled by artificial intelligence from three dimensions: reconstruction of the teaching system, innovation of teaching models, and improvement of the guarantee system. It aims to promote the in-depth integration of the two, cultivate international talents with innovative thinking, entrepreneurial competence, and artificial intelligence literacy, and provide practical references for the reform of innovation and entrepreneurship education in universities.