A Resting-state Functional Magnetic Resonance Imaging Study on Macroscale Topological Properties of Whole-brain Functional Networks in Patients with Post-traumatic Stress Disorder
Objective: To investigate alterations in resting-state functional connectivity in patients with post-traumatic stress disorder (PTSD). Methods: This was a retrospective case-control study. Forty-five patients with PTSD and 45 healthy control group (HCG) subjects were included. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed, and between-group differences in functional connectivity were compared. Results: This study did not find significant differences in macroscopic brain network functional connectivity between patients with PTSD and healthy individuals. Conclusion: There were no significant between-group differences in global efficiency, mean local efficiency, mean clustering coefficient, or number of rich-club connections of the whole-brain functional network between patients with PTSD and HCG, suggesting that brain network abnormalities in PTSD may not be changes in whole-brain macroscopic topological organization.
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