Clinical Efficacy of Spleen-strengthening and Dampness-removing Traditional Chinese Medicine Combined with Calcineurin Inhibitors in the Treatment of Moderate to Severe Atopic Dermatitis in Children and its Impact on Skin Barrier Function
Objective: To explore the clinical effect of traditional Chinese medicine for strengthening the spleen and removing dampness combined with calcineurin inhibitors in the treatment of moderate to severe atopic dermatitis in children, and the impact of this combined regimen on the skin barrier function of children. Methods: 60 children with moderate to severe atopic dermatitis admitted to our hospital from January 2025 to February 2026 were selected and divided into two groups using the random number table method, with 30 cases in each group. The control group was treated with calcineurin inhibitors alone, while the observation group was treated with traditional Chinese medicine for strengthening the spleen and removing dampness combined with calcineurin inhibitors. The total clinical treatment effectiveness, skin barrier function-related indicators before and after treatment, and the occurrence of adverse reactions were compared between the two groups of children. Results: The total effective rate of treatment in the observation group was higher than that in the control group, and the improvement in skin barrier function indicators after treatment was better than that in the control group (p < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (p > 0.05). Conclusion: Traditional Chinese medicine for strengthening the spleen and removing dampness combined with calcineurin inhibitors can effectively improve the clinical treatment effect and improve the skin barrier function of children with moderate to severe atopic dermatitis in children, and the safety of the treatment can be guaranteed.
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