With the deepening of globalization, the economic and trade cooperation between China and Vietnam has been continuously deepened, and the business exchanges have become increasingly frequent. As the key link of cooperation, the effectiveness of international business negotiation is closely related to the adaptation of the cultural characteristics of both sides. China and Vietnam have formed their own cultural characteristics in the long-term development, which have a direct impact on the negotiation process in the communication mode, cooperation goals, and other aspects. By analyzing the cultural characteristics in the commercial negotiations in the map, the paper puts forward the corresponding adaptive strategy, aiming to provide a reference for the enterprise’s smooth business cooperation.