Focusing on the archives management of infrastructure projects in scientific research institutions under the new situation, this paper conducts an in-depth analysis from two aspects: work objectives and work methods. In terms of work objectives, four goals are proposed, including improving the standardization level, strengthening information construction, ensuring security, and enhancing service efficiency. In terms of work methods, five specific practices are elaborated, such as establishing management systems, promoting information construction, intensifying personnel training, implementing quality control, and strengthening safety protection. This paper aims to provide theoretical guidance and practical reference for the archives management of infrastructure projects in scientific research institutions, so as to facilitate the efficient development of scientific research projects.