Emergency response plans are the core link in the process of dealing with unexpected incidents. However, the various types of information faced in responding to unexpected incidents are highly uncertain. Therefore, how to select a relatively satisfactory emergency response plan for unexpected incidents under uncertain information is an urgent problem to be solved in emergency management. To effectively select emergency response plans for unexpected events under uncertain information, this paper proposes a decision-making method based on the combination of the Analytic Hierarchy Process (AHP) and the fuzzy comprehensive evaluation method. Firstly, various influencing factors of emergencies are obtained through data collection and actual research. The AHP method is adopted to conduct weight analysis of the influencing factor indicators, and the key influencing factors of emergencies are obtained. Secondly, design alternative emergency response plans based on key influencing factors; Secondly, a fuzzy comprehensive evaluation model is constructed to conduct a comprehensive assessment of each alternative plan, and the best emergency response plan is determined based on the scores of the alternative plans. Finally, the feasibility of the proposed selection technology is illustrated through a research example of the campus fire emergency plan.