Against the complex and diverse backdrop of globalization and the exchange and mutual learning among civilizations, the international communication of Chinese literary works faces a new situation where opportunities and challenges coexist. This study focuses on the regionalized communication paths of Chinese literary works, aiming to address issues in current communication, such as the tendency toward homogenization, unbalanced acceptance, and insufficient communication effectiveness. The study divides the communication regions into East Asia, Southeast Asia, countries along the “Belt and Road” Initiative, and Europe and America, and analyzes the unique communication characteristics, advantages, and obstacles of each region. Based on the analysis of differences among the above-mentioned regions, three major strategies for regionalized communication are proposed. The implementation of differentiated communication strategies of “one policy for one country” and “one policy for one region” is the key to enhancing the international acceptance of Chinese literature and deepening the exchange and mutual learning among civilizations. This study attempts to provide theoretical support and practical suggestions for building an accurate and efficient regionalized communication system for Chinese literary works. It has a certain reference value for expanding the localized application of cross-cultural communication theories, helping China participate in global cultural governance, and promoting the “going global” of China’s fine traditional culture and contemporary culture.