With the rapid development of information technology, artificial intelligence has developed rapidly, and is gradually widely used in all walks of life, which has a profound impact on social development. In the field of museum exhibition design, artificial intelligence also plays a role that cannot be ignored. Relevant designers should pay attention to the role of high-tech in the information age in promoting the development of the museum industry, innovatively introduce artificial intelligence technology, and promote the development of the museum to follow the pace of the time and better cater to the needs of the audience. In this context, this paper will first briefly expound the relevant concepts of artificial intelligence and museum exhibition design, then briefly discuss the application principles of artificial intelligence in museum application in museum exhibition design, and finally explore the relevant application paths, aiming to give full play to the application value of artificial intelligence in museum exhibition design, innovative design direction, and create diversified design forms. To provide visitors with a more novel tour experience, improve the recognition of the museum at the social level, and strengthen its role in cultural construction through scientific and technological means.