Through studying the current situation of the construction of electronic information professional groups in higher vocational colleges serving the upgrading of regional information industry, this paper proposes establishing inter-school professional groups from a horizontal perspective, making appropriate adjustments on the professional groups, and actively adapting to the industrial development. On this basis, the integration of industry-education and in-depth cooperation between schools and enterprises can be realized, and the path of realizing “three-sharing, three-integration” professional group service industry upgrading is innovatively proposed.