The digital economy has emerged as a new engine driving China’s economic growth. The support of the digital economy for regional high-quality development relies on the synergy, matching, and coupling between industrial digitalization and digital industrialization. Based on an in-depth review of the literature, this paper delves into the interaction mechanism between industrial digitalization and digital industrialization. Furthermore, it explores the formation mechanism and implementation path of coupling, and from the perspective of promoting regional high-quality development, proposes targeted countermeasures and suggestions to facilitate the coupling of the two.