Safe production is the cornerstone for the sustainable development of enterprises, directly related to the safety of employees’ lives, the economic benefits of the enterprises, and social stability. Scientifically identifying potential risk factors, establishing a quantitative evaluation system, and formulating targeted prevention strategies have become key to improving safety in chemical production. This study develops a risk assessment model for safe production in chemical enterprises by integrating multiple methods, with a focus on evaluation and response strategies. Based on relevant research results, the safety risks of chemical enterprises are analyzed and an evaluation index system is constructed. The weights of risk evaluation indicators are calculated using the analytic hierarchy process and evaluated. According to the final evaluation results, combined with the current situation of the chemical industry, the risk management response strategies for safe production are proposed, which helps to achieve pre-control of risks and precise allocation of resources, and provides certain reference significance for the risk management of safe production in the chemical industry.