Under the digital economy, college students’ innovation and entrepreneurship education is facing new transformation and reform, such as increasing entrepreneurial opportunities, improving quality, and new development opportunities under the digitalization of education. This paper takes the digital economy as the development background, discusses how to build the digital innovation and entrepreneurship education ecosystem, that is, to form an integration mechanism with digital technology as the important content, digital context as the external environment, and digital organizational form as the guarantee. The specific approaches are as follows: Improve the digital skills and ability of entrepreneurs, carry out the design of digital entrepreneurship courses, strengthen the construction of digital organizations, establish a mechanism for multi-subject participation and value co-creation, and constantly promote the development of innovation and entrepreneurship education under the digital economy.