Volume 10,Issue 5
The Role of Butyrate-GPR109A Axis That Faecalibaculum rodentium Helps Control in How Sea Buckthorn Berries Extract Works Against Ulcerative Colitis
Ulcerative Colitis, also known as UC, is a long-term inflammatory bowel disease. Current clinical treatments do not work very well for it, and the disease often comes back after treatment. Imbalanced bacteria in the gut is one of the main reasons why this disease develops. Sea buckthorn berry extract, which is called SBE here, is already used in clinics to treat colitis, but no one is really sure how exactly it works. In this study, we built an acute UC mouse model by inducing it with dextran sulfate sodium, which is also called DSS. We did the research by combining 16S rRNA sequencing, co-housing tests, and experiments that let us colonize the microbes in the gut. The results show that SBE made UC symptoms a lot better in these mice, and the effect it had was similar to 5-amino salicylic acid (5-ASA), sometimes even better. If we look at the actual mechanism, SBE increased the amount of Faecalibaculum rodentium (F. Rodentium) in the mouse gut. This bacterium helps the body make more butyric acid (BA). BA then connects to the GPR109A receptors that are on colon epithelial cells, which lowers the inflammation in that area. This finding gives people a totally new way to do microbe-targeted therapy when treating UC.
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