Clinical Analysis of Endoscopic Esophageal Dilation Combined with Mitomycin in the Treatment of Corrosive Esophageal Stenosis in Children

© 2025 by the Authors. Licensee: Bio-Byword Scientific Publishing Pty Ltd, Australia. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Objective: To explore the clinical application of endoscopic esophageal dilation combined with mitomycin in the treatment of corrosive esophageal stenosis in children. Methods: Twenty children with corrosive esophageal stenosis treated in our hospital from August 2023 to March 2025 were selected and divided into an intervention group (n = 10, combined with mitomycin) and a control group (n = 10, simple dilation) according to the treatment plan. The Stooler swallowing grade, diameter of the stenotic segment, total effective rate, number of dilations, and complications were compared between the two groups before and after treatment. Results: After treatment, the swallowing function improved in both groups, but the increase in the diameter of the stenotic segment was greater in the intervention group (P < 0.05), and the total effective rate was higher (P < 0.05). The average number of dilations in the intervention group (3.20 ± 1.03) was significantly less than that in the control group (5.00 ± 1.63) (P < 0.05). There was no statistical difference in the incidence of complications between the two groups, mainly mild bleeding and chest pain. Conclusion: Combined mitomycin can improve efficacy, reduce treatment frequency, and has good safety, which is worthy of priority clinical application.

References

Qi K, Zeng L, Wang C, et al., 2025, Research Progress on Drug Therapy for Corrosive Esophageal Strictures in Children. International Journal of Pediatrics, 52(1): 22–26.

Sarma M, Tripathi P, Arora S, 2021, Corrosive Upper Gastrointestinal Strictures in Children: Difficulties and Dilemmas. World Journal of Clinical Pediatrics, 10(6): 124–136.

Tang L, Lou J, Zhao H, et al., 2023, Clinical Analysis of Endoscopic Esophageal Dilation for the Treatment of Corrosive Esophageal Strictures in Children. Chinese Journal of Contemporary Pediatrics, 25(12): 1265–1269.

Youn B, Kim W, Cheon J, et al., 2010, Balloon Dilatation for Corrosive Esophageal Strictures in Children: Radiologic and Clinical Outcomes. Korean Journal of Radiology, 11(2): 203–210.

Sweed A, Fawaz S, Ezzat W, et al., 2015, A Prospective Controlled Study to Assess the Use of Mitomycin C in Improving the Results of Esophageal Dilatation in Post-Corrosive Esophageal Stricture in Children. International Journal of Pediatric Otorhinolaryngology, 79(1): 23–25.

Isa H, Hasan K, Ahmed H, et al., 2021, Efficacy and Safety of Endoscopic Esophageal Dilatation in Pediatric Patients with Esophageal Strictures. International Journal of Pediatrics, 2021: 1277530.

Yu Y, Xia Q, Liao Y, 2021, Preventive and Therapeutic Effects of Comprehensive Management of Body Position and Drugs on Esophageal Stenosis After Endoscopic Submucosal Dissection. Minimally Invasive Medicine, 16(4): 583–585.

Repici A, Vleggaar F, Hassan C, et al., 2010, Efficacy and Safety of Biodegradable Stents for Refractory Benign Esophageal Strictures: The BEST (Biodegradable Esophageal Stent) Study. Gastrointestinal Endoscopy, 72(5): 927–934.

Tarek S, Mohsen N, Abd El-Kareem D, et al., 2020, Factors Affecting the Outcome of Endoscopic Dilatation in Refractory Post-Corrosive Oesophageal Stricture in Egyptian Children: A Single-Centre Study. Esophagus, 17(3): 330–338.

Uygun I, 2015, Caustic Oesophagitis in Children: Prevalence, the Corrosive Agents Involved, and Management from Primary Care Through to Surgery. Current Opinion in Otolaryngology & Head and Neck Surgery, 23(6): 423–432.

Dall’Oglio L, Caldaro T, Foschia F, et al., 2016, Endoscopic Management of Esophageal Stenosis in Children: New and Traditional Treatments. World Journal of Gastrointestinal Endoscopy, 8(4): 212–219.

Flor M, Ribeiro I, De Moura D, et al., 2021, Efficacy of Endoscopic Topical Mitomycin C Application in Caustic Esophageal Strictures in the Pediatric Population: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Arquivos de Gastroenterologia, 58(2): 253–261.

Berger M, Ure B, Lacher M, 2012, Mitomycin C in the Therapy of Recurrent Esophageal Strictures: Hype or Hope? European Journal of Pediatric Surgery, 22(2): 109–116.

El-Asmar K, Hassan M, Abdelkader H, et al., 2013, Topical Mitomycin C Application Is Effective in Management of Localized Caustic Esophageal Stricture: A Double-Blinded, Randomized, Placebo-Controlled Trial. Journal of Pediatric Surgery, 48(7): 1621–1627.

Ghobrial C, Eskander A, 2018, Prospective Study of the Effect of Topical Application of Mitomycin C in Refractory Pediatric Caustic Esophageal Strictures. Surgical Endoscopy, 32(12): 4932–4938.

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