Objective: To explore the key points of early identification and comprehensive nursing intervention strategy for necrotizing fasciitis patients, to improve the efficiency of clinical diagnosis and treatment and the quality of prognosis. Methods: The clinical data of a 70-year-old female patient with right-hand trauma complicated by infection progressing to necrotizing fasciitis were reviewed and analyzed. Laboratory, imaging, and surgical findings were integrated to summarize the early identification features and key nursing considerations. Results: The patient retained the affected limb, albeit with some functional limitations, following early identification, timely surgical debridement, broad-spectrum anti-infective therapy, and comprehensive nursing care. Conclusion: The early clinical manifestations of necrotizing fasciitis are often subtle, and the disease progresses rapidly. This necessitates heightened vigilance among medical staff in all healthcare settings. Implementing multidisciplinary collaboration and systematic nursing interventions can improve patient prognosis while reducing amputation rates and mortality.