Volume 10,Issue 9
Effect of Early Fluid Resuscitation on Recovery of Coagulation Function in Acute Traumatic Coagulopathy
Objective: To investigate the actual impact of early fluid resuscitation on the recovery of coagulation function in patients with acute traumatic coagulopathy (ATC). Methods: Fifty patients with acute traumatic coagulopathy admitted to our hospital from June 1, 2025 to June 30, 2026 were selected as study subjects. All patients were divided into two groups using the random number table method, with 25 cases in each group. The control group received conventional fluid resuscitation, while the observation group received early restrictive fluid resuscitation. Coagulation function indicators, blood gas analysis indicators, inflammatory factor indicators, and prognosis-related indicators were compared between the two groups. Results: At 24 h after intervention, the observation group had PT (13.25 ± 1.12) s, APTT (32.46 ± 2.31) s, FIB (2.87 ± 0.34) g/L, and D (1.82 ± 0.41) mg/L, while the control group had PT (15.78 ± 1.46)s, APTT (38.72 ± 2.85) s, FIB (2.15 ± 0.28) g/L, and D (3.24 ± 0.57) mg/L. The differences in coagulation function indicators between the two groups were statistically significant (p < 0.05). Among blood gas analysis indicators, the
observation group had pH (7.38 ± 0.03), PaO₂ (87.64 ± 5.21) mmHg, and lactate (2.13 ± 0.36) mmol/L, which were superior to the control group’s pH (7.32 ± 0.04), PaO₂ (78.53 ± 4.89) mmHg, and lactate (3.47 ± 0.52) mmol/L, with statistically significant differences (p < 0.05); there was no statistically significant difference in PaCO₂ between the two groups (p > 0.05). Among inflammatory factor indicators, the observation group had TNF-α (18.52 ± 3.14) ng/L and IL-6 (22.47 ± 3.56) ng/L, which were lower than the control group’s TNF-α (32.65 ± 4.72) ng/L and IL-6 (38.79
± 4.21) ng/L, with statistically significant differences (p < 0.05); there was no statistically significant difference in IL-1β between the two groups (p > 0.05). Among prognosis-related indicators, there were no statistically significant differences in total hospitalization duration, 28-day mortality, or incidence of bleeding-related complications between the two groups (p > 0.05). Conclusion: Early restrictive fluid resuscitation can, to a certain extent, modulate the coagulation status, blood gas levels, and degree of inflammatory response in ATC patients, without bringing additional negative effects on long-term outcomes, and can provide a reference for the formulation of acute-phase intervention protocols for clinical acute trauma patients.
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