As China’s higher education transitions from extensive expansion to intensive development, the ‘New Liberal Arts’ concept has emerged as a pivotal strategic direction for transforming humanities disciplines. This approach emphasizes interdisciplinary integration, parallel development of theory and practice, and optimizing talent cultivation models guided by societal demands. The diversified economic structure and high-quality development trajectory of the Guangdong-Hong Kong-Macao Greater Bay Area present new demands for talent cultivation, curriculum design, and pedagogical reform within university Human Resource Management (HRM) programs. Taking Guangzhou Huashang College as the research subject, this paper analyses the core competencies required for HRM programs under the New Liberal Arts framework through policy document analysis, literature review, and field research. It identifies shortcomings in the current curriculum system regarding knowledge structure, practical pathways, and cross-disciplinary integration. Guided by Outcome-Based Education (OBE) and Competency-Based Education (CBE) frameworks, a new curriculum architecture was designed comprising four pillars: general education and humanities literacy, professional core competencies, cross-disciplinary integration, and practical innovation. Practical explorations were undertaken in areas such as university-enterprise collaboration and industry-education integration. Preliminary outcomes demonstrate that the new scheme comprehensively enhances students’ data comprehension, strategic awareness, and humanistic sensitivity, providing a reference paradigm for the high-quality development of HRM programs within the new liberal arts context.