Objective: To investigate and analyze the clinical effectiveness of intense pulsed light combined with Q-switched laser in facial skin beauty treatment. Methods: A total of 197 patients with post-acne pigmented spots and erythema seeking facial skin beauty treatment in our hospital from May 2024 to May 2025 were selected and randomly divided into observation group (99 cases) and control group (98 cases) according to the envelope method. The control group was treated with a Q-switched laser, while the observation group was treated with intense pulsed light combined with a Q-switched laser. The clinical effectiveness, Melasma Area and Severity Index (MASI) score, and skin barrier function (stratum corneum water content, transepidermal water loss, epidermal sebum content) were compared between the two groups. Results: The clinical effectiveness of the observation group was significantly better than that of the control group (P < 0.05). There was a statistically significant difference in the decrease of MASI scores between the observation group and the control group (P < 0.05). After treatment, the levels of transepidermal water loss and epidermal sebum content in both groups were significantly reduced, and the water content of the stratum corneum was significantly increased. The improvement of each index in the observation group was better than that in the control group (P < 0.05). Conclusion: The combination of intense pulsed light and Q-switched laser can not only improve the clearance rate of skin lesions, but also achieve an overall improvement in skin barrier function by promoting collagen regeneration, optimizing epidermal hydration function, and sebum metabolism.