Objective: To investigate the clinical efficacy of mobile moxibustion cupping combined with electroacupuncture in patients with wind-cold-dampness scapulohumeral periarthritis. Methods: A total of 70 patients with wind-cold-dampness scapulohumeral periarthritis treated in the orthopedic department of our hospital from September 2023 to January 2024 were enrolled and divided into two groups via random number table, with 35 cases in each group. The control group received electroacupuncture monotherapy, while the observation group was treated with additional mobile moxibustion cupping. Shoulder VAS pain score, Constant-Murley shoulder function score, WHOQOL-BREF quality of life score and TCM syndrome score were compared before and after treatment; the total effective rate and adverse reactions were recorded. Results: No statistically significant intergroup differences were found in all baseline indicators before intervention (P＞0.05). After treatment, the observation group obtained higher Constant-Murley and quality of life scores, as well as lower VAS and TCM syndrome scores than the control group (P＜0.05). All indicators in both groups were significantly improved compared with baseline (P＜0.05). The total effective rate reached 94.29% in the observation group, which was remarkably higher than 77.14% of the control group (P＜0.05). No adverse reactions such as skin scald, acupuncture syncope or allergy occurred during treatment. Conclusion: Combined therapy of mobile moxibustion cupping and electroacupuncture can relieve shoulder pain, ameliorate shoulder mobility and wind-cold-dampness TCM symptoms, and improve patients’ daily function and quality of life. With superior efficacy and high safety, this combined regimen is worthy of clinical promotion.