Purpose: This article aims to discuss five medical intervention strategies required for patients with amyotrophic lateral sclerosis (ALS) and provide a reference for intervening in this challenging disease. Methods: A retrospective analysis was conducted to identify existing issues in the treatment of ALS patients. A comparative analysis was performed to examine the nature, characteristics, and methods of previous intervention approaches. Results: Early identification and intervention, the application of rational combined treatment approaches, the improvement of comprehensive physical and mental rehabilitation systems, and the exploration of new treatment strategies provide a guarantee for effective intervention treatment of ALS patients. Conclusion: This article proposes the addition of a combined treatment approach involving the elimination of excessive glutamate from the body, which is theoretically reasonable, safe, and simple to implement. This approach has the potential to enhance the therapeutic effects and improve the individual prognosis of ALS patients. Given the lack of specific therapeutic drugs, further research on an effective combined intervention approach remains necessary.