Long non-coding RNA LINC01123 facilitates the progression of lung cancer by targeting miR-384
Purpose: Although growing evidence has demonstrated that LINC01123 plays an oncogenic role in lung cancer, the underlying mechanisms require further elucidation. Methods: To explore the functions of LINC01123 on cell proliferation and migration, CCK-8 and Transwell assays were performed. The relationships between LINC01123 and miR-384 were examined by luciferase reporter assays. The expression of LINC01123 and miR-384 was quantified by quantitative real-time PCR. Results: In this study, knockdown of LINC01123 inhibited cell proliferation and migration, while overexpression of LINC01123 enhanced these effects in lung cancer. Luciferase reporter assays verified that LINC01123 could bind directly to miR-384. Overexpression of miR-384 suppresses cell proliferation and migration. The results of the rescue experiment showed that knockdown of LINC01123 inhibited cell proliferation and migration, whereas inhibition of miR-384 counteracted the repressive effects induced by LINC01123 inhibition. Conclusion: Our study reveals that LINC01123 promotes lung cancer progression via miR-384 for the first time.
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